Publications arising from BMA research grants
Updated July 2008
2006
Margaret Temple – Genetic and psychological correlates of brain structure and function in children at high and low risk for developing schizophrenia: Dr K Laurens
Laurens KR, Hodgins S, Maughan B et al (2007)Community screening for psychotic-like experiences and other putative antecedents of schizophrenia in children aged 9-12 years. Schizophrenia Research 90: 130-46.
2005
Dawkins & Lawson – Dardarin: a ROCO family protein kinase involved in Alzheimers’s disease: Dr K Harvey
Greggio E, Jain S, Kingsbury A et al (2006) Kinase activity is required for the toxic effects of mutant LRRK2/dardarin. Neurobiology of Disease 23: 329–41.
Lansdell & Lawson – The role of protease activated receptors in the human vasculature: Dr I Gudmundsdóttir
Gudmundsdóttir IJ, Megson IL, Kell JS et al (2006) Direct Vascular Effects of Protease-Activated Receptor Type 1 Agonism In Vitro in Humans. Circulation 114: 1625-32.
Gunton & Tomkinson - Predictive models of cancer incidences attributable to smoking versus obesity-related risk factors for UK and three other countries
Renehan AG, Tyson M, Egger M et al (2008) Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies. Lancet 371 (9612): 536-7.
2004
The James Trust - The pathology of infant wheezing and the origins of asthma in children: Dr Sejal Saglani
Saglani S, Malmstrom K, Pelkonen AS et al (2005) Airway Remodeling and Inflamation in Symptomatic Infants with Reversible Airflow Obstruction. American Journal of Critical Care and Respiratory Medicine, 171: 722-7.
Margaret Temple - Cerebral Connectivity in Schizophrenia: Ms Anna Plodowski
A preliminary account on this work was reported at the Winter Workshop on Schizophrenia in Davos, 2006, and an abstract published in the journal Schizophrenia Research (Liddle et al, 2006).
Aberrant low frequency oscillatory activity in adolescent onset schizophrenia and siblings on an error monitoring task. Schizophrenia Research 81S, 13.
HC Roscoe - Activation of innate responses and apoptosis in bronchiolar epithelial cells by influenza virus and its haemagglutinin: Dr Stuart Marshall-Clarke
Marshall-Clarke S, Downes JE, Haga IR et al (2007) Polyinosinic Acid Is a Ligand for Toll-like Receptor 3. The Journal of Biological Chemistry, 282 (34): 24759-66.
Doris Hillier - Effects of statin or ezetimibe treatment on measurements of T cell and monocyte/macrophage function in patients with rheumatoid arthritis: Dr FC Hall
Maki-Petaja KM, Booth AD, Hall FC et al (2007) Ezetimibe and simvastatin reduce inflammation, disease activity, aortic stiffness and improve endothelial function in rheumatoid arthritis. Journal of the American College of Cardiology, 50: 852-8.
2003
Doris Hillier - A study of the mechanical properties and long term release profile of bone cements loaded with single & multiple antibiotics: Mr J Webb
Webb JCJ & Spencer RF (2007) The role of polymethylmethacrylate bone cement in modern orthopaedic surgery. The Journal of Bone and Joint Surgery, 89-B, Issue 7, 851-7.
HC Roscoe - Rhinovirus infection and activation of asthmatic epithelial-mesenchymal trophic unit: Dr Peter Wark
Wark P, Johnston SL, Bucchieri F et al (2005) Asthmatic bronchial epithelial cells have a deficient innate immune response to infection with rhinovirus, The Journal of Experimental Medicine 201(6): 937-47.
Wark P, Bucchieri F, Johnston SL et al (2007) IFN-gamma-induced protein 10 is a novel biomarker of rhinovirus-induced asthma exacerbations.Journal of Allergy and Clinical Immunology 120(3): 586-93.
HC Roscoe - Role of IL12 / IL18 / IL23 in rhinovirus induced exacerbations of asthma: Dr Simon Message
Contoli M, Message SD, Laza-Stanca V et al (2006) Role of deficient type III interferon-lambda production in asthma exacerbations, Natural Medicine 12: 1023-6.
Sir Charles Hastings & Charles Oliver Hawthorne - Effect of Non-Principal (NP) Support/Education Groups on Local Retention of GPs: Dr Catherine Jenson
Rowlands G & Jenson R (2004) Supplementary list inaccuracy - implications for clinical governance? British Journal of General Practice, 54: 302.
Jenson CM, Hutchins AJ & Rowlands G (2006) Is small-group education the key to retention of sessional GPs? Education for Primary Care, 17 (3): 218-26.
Margaret Temple – Why is Clozapine a much better antipsychotic than Haloperidol? A molecular approach using microarray screening of gene expression changes: Dr Mie A Rizig
Rizig MA, McQuillin A, Puri V et al (2006) Failure to confirm genetic association between schizophrenia and markers on chromosome 1q23.3 inn the region of the gene encoding the regulator of G-protein signalling 4 protein (RGS4). American Journal of Medical Genetics. Part B. Neuropsychiatric Genetics, 141(3): 296-300.
Presentations:
A gene expression study of Clozapine compared to Haloperidol and how these drugs interact with genes implicated in schizophrenia. Oral Presentation in the 13th World Congress on psychiatric genetics. Boston, USA. Oct 2005.
The molecular pharmacology behind the antipsychotic and antimanic effects of Clozapine: Microarray gene expression profiles of the conventional antipsychotic Haloperidol compared to the atypical antipsychotic Clozapine. Invited speaker in The European Stanley Bipolar Conference, Aarhus, Denmark. Sept 2004.
A microarray gene expression and genetic association study of the RGS4 gene in schizophrenia. Oral presentation in the 12th World Congress of psychiatric genetics. Dublin, Ireland. Oct 2004.
Microarray comparison of CNS gene expression changes in response to Clozapine compared to Haloperidol and controls: What genes predict the therapeutic efficacy and side effects of antipsychotics? Oral presentation in the 11th World Congress on psychiatric genetics. Quebec, Canada. Oct 2003.
Vera Down – Extracellular Cathepsin S proteinase is astrocytomas in vitro: its clinical relevance and role invasion: Mr T Flannery
Flannery T, McConnell RS, McQuaid S et al (2007) Detection of cathepsin S cysteine protease in human brain tumour microdialysates in vitro. British Journal of Neurosurgery, 21(2):204-9.
2002
Brackenbury - Use of lipid lowering drugs among minority ethnic groups: Dr Paramjit Singh Gill
Gill PS, Quirke TP, Mant JW et al (2004) The use of lipid-lowering drugs across ethnic groups in the secondary prevention of ischaemic heart disease: analysis of cross-sectional surveys in England. British Journal of General Practice, 54: 442-3.
Poster presentations: 15th Annual Scientific Meeting of the UK Drug Utilisation Research Group, Nottingham, UK, January 2004; 6th Annual Conference of the UK Federation of Primary Care Research Networks, Birmingham, UK, November 2003.
TP Gunton - Complementary medicine (CM) for cancer: Miss Katja Schmidt
Roffe L, Schmidt K, Ernst E et al (2004) Efficacy of coenzyme Q10 for improved tolerability of cancer treatments: A systematic review. Journal Clinical Oncology, 22: 4418-24.
Roffe L, Schmidt K, Ernst E et al (2005) A systematic review of guided imagery as a supportive cancer care. Psycho-Oncology, 14 (8): 607-17.
Bridging the gap between researchers and practitioners: a report from a survey of naturopathic medicine practitioners, International Journal of Naturopathic Medicine. 2004, 1(1):43-8.
2001
John William Clark - Drug induced regression of retinal neovacularization: Dr Anna-Maria Demetriades
Gehlbach P, Demetriades A-M, Yamamoto S et al (2003) Periocular gene transfer of sFlt-1 suppresses ocular neovascularization and vascular endothelial growth factor-induced breakdown of the blood-retinal barrier. Human Gene Therapy, 14: 129-41.
Presentations: Periocular adenovirus-mediated delivery of the extracellular portion of vascular endothelial growth factor receptor-1 inhibits choroidal neovascularization, made to the 13th Annual Wilmer Eye Institute Research Meeting, USA, March 2002; Transscleral delivery of proteins by periocular gene transfer, made to the Association for Research in Vision and Ophthamology Annual Conference, Florida, USA, May 2003.
Joan Dawkins (Housing and Health) - Patient contact versus council tax valuation band: Dr Norman Beale
Beale N, Gywnne M & Peart C (2004) Council tax banding and missed appointments. British Journal of General Practice, 54: 304.
Beale N, Taylor G, Straker-Cook D et al (2005) Council tax valuation band of patient residence and clinical contacts in a general practice. British Journal of General Practice 55: 32-6.
Elizabeth Wherry and Charlotte Eyck - Role of nephrin dysregulation in childhood nephrotic syndromes: Dr Richard Coward
Presentations: The podocyte is an insulin responsive, glucose utilizing cell; with a functional IRS1/GLUT4/VAMP2 apparatus. A potential target cell in diabetic nephropathy, made to the Renal Association, 2002; Plasma from children with focal segmental glomerulosclerosis affects the podocyte cytoskeleton, cell differentiation and function, made to RCPCH York meeting, 2002.
HC Roscoe - Mechanisms of bronchial epithelial cell activation in rhinovirus infection in asthma, chronic obstructive pulmonary disease and normal airways: Dr Peter Wark
Wark AB, Johnston SL, Bucchieri et al (2005) Asthmatic bronchial epithelial cells have a deficient innate immune response to infection with rhinovirus. Journal of Experimental Medicine, 201: 937-47.
Presentations: Induction of cytotoxicity in an epithelial cell line following infection with rhinovirus, made to The American Thoracic Society ASM - Seattle, USA, 2003; Cytotoxic effects of infection with rhinovirus on asthmatic primary bronchial epithelial cells, made to The European Respiratory Society First Scientific Assembly, Taormina, Sciliy, 2003.
Margaret Temple - Testing the subplate model of schizophrenia: Dr Sharon Eastwood
Eastwood SL & Harrison PJ (2003) Interstitial white matter neurons express less reelin and are abnormally distributed in schizophrenia: towards an integration of molecular and morphologic aspects of the neurodevelopmental hypothesis. Molecular Psychiatry 8: 821-31.
Eastwood SL & Harrison PJ (2005) Interstitial white matter neuron density in the dorsolateral prefrontal cortex and parahippocampal gyrus in schizophrenia. Schizophrenia Research 79: 181-8.
Eastwood SL & Harrison PJ (2006) Cellular Basis of Reduced Cortical Reelin Expression in Schizophrenia. American Journal of Psychiatry, 163: 540-2.
2000
Margaret Temple - The Anatomical and Pharmacological substrate of memory impairment in Schizophrenia: Dr C Stephenson
Menzies L, Ooi C, Kamath s et al (2007) Effects of gamma-aminobutyric acid-modulating drugs on working memory and brain function in patients with schizophrenia. Archives of General Psychiatry 64: 156-67.
T P Gunton - Strategies for rehabilitation and education in adults with malignant cerebral glioma: Dr Elizabeth Davies
Davies E & Higginson IJ (2003) Communication, information and support for adults with malignant cerebral glioma: a systematic literature review. Support Care Cancer, 11: 21-9.
Davies E, Hall S, Clarke C (2003) Two year survival after malignant cerebral glioma: patient and relative reports of handicap, psychiatric symptoms and rehabilitation. Disability and Rehabilitation, 25: 259-66.
C H Milburn and Samuel Strutt - Crime scenes: Dr Guy Rutty
Rutty GN, Hopwood A & Tucker V (2003)The effectiveness of protective clothing in the reduction of potential DNA contamination of the scene of crime. International Journal of Legal Medicine, 117: 170-4.
Elizbeth Wherry and Charlotte Eyck - Familial cystic renal disease: Dr Coralie Bingham
Bingham B, Ellard S, Cole TRP et al (2002) Solitary functioning kidney and diverse genital tract malformations associated with hepatocyte nuclear factor-1 beta mutations. Kidney International, 61: 1243-51.
Doris Odlum and Samuel Strutt - Impact of witnessing a suicide attempt in a young offenders' institution: Dr Heidi Hales
Hales H, Davison S, Misch P et al (2003)Young male prisoners in a young offenders' institution: their contact with suicidal behaviour by others. Journal of Adolescence, 26: 667-85.
Helen Tomkinson & Albert McMaster - The role of MAP kinase kinase-5 (MEK5) in prostate cancer: Dr Benjamin Jenkins
Mehta PB, Jenkins BL, McCarthy L et al (2003) MEK5 overexpression is associated with metastatic prostate cancer, and stimulates proliferation, MMP-9 expression and invasion. Oncogene 22: 1381-9.
1999
John William Clark - Wolfram Syndrome: Dr Timothy G Barrett
Hardy C, Khanim F, Torres R et al (1999) Clinical and molecular genetic analysis of 19 Wolfram Syndrome kindreds demonstrating a wide spectrum of mutations in WFS1. American Journal of Human Genetics, 65: 1279-90.
Barrett T, Scott-Brown M, Seller A et al (2000) The mitochondrial genome in Wolfram syndrome. Journal of Medical Genetics, 37: 463-6.
Joan Dawkins - Osteoarthritis and ex-professional footballers: Andy Turner, Julie Barlow & Brian Ilbery
Turner A, Barlow J & Ilbery B (2002) Play hurt, live hurt: living with and managing osetoarthritis from the perspective of ex-professional footballers. Journal of Health Psychology, 7: 285-301.
Nathaniel Bishop Harman - Glaucoma: Mr Michael Greaney
Presentations: Association for Research in Vision and Ophthalmology Annual Meeting, Florida, USA, May 2000; European Glaucoma Society Annual Meeting, London, UK, June 2000.
Edith Walsh - Protection of human heart against myocardial stunning by ischemic preconditioning: Mr Sudip Ghosh
Gnosh S, Ng LL, Talwar S et al (2000) Cardiotrophin-1 protects the human myocardium from ischemic injury: Comparison with the first and second window of protection by ischemic preconditioning. Cardiovascular Research, 48: 440-7.
Loubani M, Ghosh S, Galiñanes M et al (2002) The aging human myocardium: Tolerance to ischemia and responsiveness to ischemic preconditioning. Cardiopulmonary Support and Physiology, 126: 143-7.
Ghosh S & Galiñanes M (2002)Protection of the human heart with ischemic preconditioning during cardiac surgery: Role of cardiopulmonary bypass. Cardiopulmonary Support and Physiology, 126: 133-42.
1998
John William Clark - Blindness: Mr Colin E Willoughby
Eye problems and ectodermal dysplasia - available at www.ectodermaldysplasia.org/med_welcome.asp
Katherine Bishop Harman - Human reproduction: Dr Kelvin J H Lim
Lim KJH, Odukoya OA, Ajjan RA et al (2000) The role of T-helper cytokines in human reproduction. Fertility & Sterility, 73: 136-42.
Doris Odlum - Lithium and serotonin reuptake inhibitors: Dr Christopher J Hawley
Hawley CJ, Loughlin PJ, Quick SJ et al (2000) Efficacy, safety and tolerability of combined administration of lithium and selective serotonin reuptake inhibitors: a review of the current evidence. International Clinical Psychopharmacology, 15: 197-206.
1997
H C Roscoe - BCG expressing latency-associated peptide: Dr Ben Marshall
Marshall BG, Wangoo A, O'Gaora P et al (2001) Enhanced antimycobacterial response to recombinant mycobacterium bovis BCG expressing latency-associated peptide. Infection and Immunity, 69: 6676-82.
Joan Dawkins - Smoke alarms: Dr Ian Roberts
DiGuiseppi C, Roberts I & Li L (1998) Smoke alarm ownership and house fire deaths in children. Journal of Epidemiology and Community Health, 52: 760-1.
Joan Dawkins (Education) - Complementary medicine: Dr George Lewith
Lewith GT & Owen D (2000) Complementary medicine: The Southampton undergraduate experience. Complementary Therapies in Medicine, 8: 202-6.
Joan Dawkins - Clinical Audit: Dr Guy R K Fender
Fender GRK, Prentice A, Nixon RM et al (2001) Management of menorrhagia: an audit of practices in the Anglia menorrhagia education study. British Medical Journal, 322: 523-4.
Doris Hillier - Systemic Lupus Erythematosus: Dr Colin Tench
Tench CM, McCurdie I, White PD et al (2000) The prevalence and associations of fatigue in systemic lupus erythematosus. Rheumatology (Oxford), 39: 1249-54.
Insole - Prostate cancer: Mr Philip A Cornford
Cornford P, Evans J, Dodson A et al (1999) Protein kinase C isoenzyme patterns characteristically modulated in early prostate cancer. American journal of Pathology, 154: 137-44.
Edith Walsh - Myocardial infarction: Dr Diana A Gorog
Gorog DA, Ahmed N & Davies GJ (1999) Platelet reactivity and streptokinase resistance following antecedent streptokinase therapy for myocardial infarction. Cardiology, 91: 56-9.
Elizabeth Wherry - Nephrotic syndromes: Dr Moin A Saleem
Presentations: American Society of Nephrology 33rd Annual Meeting, Toronto, Canada, Oct 2000; Podocyte Biology Symposium, Ann Arbor, Michigan, USA, Sept 2000; European Society for Paediatric Nephrology, Helsinki, Finland, Jun 2000; UK Renal Association, London, UK, Spring 2000; UK Renal Association 50th Anniversary Meeting, Autumn 2000.