To maximise recall (sensitivity, or comprehensiveness)
use MeSH terms with keywords
explode MeSH terms
select the All Subheadings option
incorporate synonyms using or
use truncation ($) and wildcards (#, ?)
refine the search by looking for additional suitable search terms (look at records that give a good match)
search as far back in time as possible
consider other databases To optimise relevance (specificity)
use MeSH headings only rather than MeSH with keywords
make the MeSH headings as specific as possible
focus MeSH terms
use MeSH subheadings
add in other terms (using and) to represent extra concepts in the question
use limits (including filters)
consider title-only searching
A good balance between recall and relevance is often achieved by using MeSH headings plus title field searching. Inconsistently indexed yet relevant records can be retrieved using title keywords without swamping the search result. Unless you need to be comprehensive, using keywords too liberally with MeSH headings can cancel out the advantages that the controlled vocabulary of the MeSH terms bring.